Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate
Chemical synthesis and characterization of a lipophilic ester conjugate, propofol stearate and evaluation of its anticancer efficacy on human breast cancer cell lines MDA-MB-361, MCF-7 and MDA-MB-231. The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its...
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| Veröffentlicht in: | Anticancer research 2013-06, Vol.33 (6), p.2517-2524 |
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| container_title | Anticancer research |
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| creator | Khan, Azmat Ali Alanazi, Amer M Jabeen, Mumtaz Chauhan, Arun Abdelhameed, Ali Sabir |
| description | Chemical synthesis and characterization of a lipophilic ester conjugate, propofol stearate and evaluation of its anticancer efficacy on human breast cancer cell lines MDA-MB-361, MCF-7 and MDA-MB-231.
The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its anticancer potential was evaluated on the basis of growth inhibition, cancer cell adhesion and migration and apoptosis induction.
Propofol stearate exhibited significant (p |
| format | Article |
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The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its anticancer potential was evaluated on the basis of growth inhibition, cancer cell adhesion and migration and apoptosis induction.
Propofol stearate exhibited significant (p<0.05) growth inhibition of breast cancer cells in a concentration-dependent manner. MDA-MB-231 cells showed highest susceptibility towards the inhibitory effect of the conjugate. Moreover, treatment of MDA-MB-231 cancer cells with 25 μM propofol stearate potentially suppressed their adhesion (~34%) and migration (~41%), and induced apoptosis (~25%).
Exogenously-applied stearic acid as an ester derivative, inhibits the growth of human breast cancer cells and shows a beneficial role in the treatment of breast cancer, in vitro.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 23749903</identifier><language>eng</language><publisher>Greece</publisher><subject>Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Apoptosis - drug effects ; Breast Neoplasms - drug therapy ; Cell Adhesion - drug effects ; Cell Line, Tumor ; Cell Movement - drug effects ; Cell Proliferation - drug effects ; Drug Design ; Esters - chemistry ; Female ; Humans ; Propofol - analogs & derivatives ; Propofol - chemical synthesis ; Propofol - chemistry ; Propofol - pharmacology ; Stearates - chemical synthesis ; Stearates - chemistry ; Stearates - pharmacology ; Stearic Acids - chemistry</subject><ispartof>Anticancer research, 2013-06, Vol.33 (6), p.2517-2524</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23749903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Azmat Ali</creatorcontrib><creatorcontrib>Alanazi, Amer M</creatorcontrib><creatorcontrib>Jabeen, Mumtaz</creatorcontrib><creatorcontrib>Chauhan, Arun</creatorcontrib><creatorcontrib>Abdelhameed, Ali Sabir</creatorcontrib><title>Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Chemical synthesis and characterization of a lipophilic ester conjugate, propofol stearate and evaluation of its anticancer efficacy on human breast cancer cell lines MDA-MB-361, MCF-7 and MDA-MB-231.
The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its anticancer potential was evaluated on the basis of growth inhibition, cancer cell adhesion and migration and apoptosis induction.
Propofol stearate exhibited significant (p<0.05) growth inhibition of breast cancer cells in a concentration-dependent manner. MDA-MB-231 cells showed highest susceptibility towards the inhibitory effect of the conjugate. Moreover, treatment of MDA-MB-231 cancer cells with 25 μM propofol stearate potentially suppressed their adhesion (~34%) and migration (~41%), and induced apoptosis (~25%).
Exogenously-applied stearic acid as an ester derivative, inhibits the growth of human breast cancer cells and shows a beneficial role in the treatment of breast cancer, in vitro.</description><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Drug Design</subject><subject>Esters - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Propofol - analogs & derivatives</subject><subject>Propofol - chemical synthesis</subject><subject>Propofol - chemistry</subject><subject>Propofol - pharmacology</subject><subject>Stearates - chemical synthesis</subject><subject>Stearates - chemistry</subject><subject>Stearates - pharmacology</subject><subject>Stearic Acids - chemistry</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlb_guTowYV8Z3OUqlUoeNGbsMwm2ZqyzdYkW-i_d8F69vS88_IwDHOG5lQbWmnJyTmaEyZJpQmRM3SV85YQpUzNL9GMcS2MIXyOPh99Dpt4j_Mxlq8pZwzR4RDxIZQ0TEMJFqL1CfsD9COUMEQ8dBhwLh5SsBhscFUL2Tvspy5hO8TtuIHir9FFB332Nycu0Mfz0_vypVq_rV6XD-tqz4QoFROu9pJRYSgT1FHgToKwHRgP3k0QxtrWdbyujW4JCGo0ASlVLZlineELdPe7d5-G73E6otmFbH3fQ_TDmBsqKJOSaUn-V7lSUkuh-KTentSx3XnX7FPYQTo2f8_jP874a94</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Khan, Azmat Ali</creator><creator>Alanazi, Amer M</creator><creator>Jabeen, Mumtaz</creator><creator>Chauhan, Arun</creator><creator>Abdelhameed, Ali Sabir</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201306</creationdate><title>Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate</title><author>Khan, Azmat Ali ; Alanazi, Amer M ; Jabeen, Mumtaz ; Chauhan, Arun ; Abdelhameed, Ali Sabir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p244t-24d8e521491241d1a3d5a4cfa9eaedfa949ccbdf38897b0a41970a55685262f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Drug Design</topic><topic>Esters - chemistry</topic><topic>Female</topic><topic>Humans</topic><topic>Propofol - analogs & derivatives</topic><topic>Propofol - chemical synthesis</topic><topic>Propofol - chemistry</topic><topic>Propofol - pharmacology</topic><topic>Stearates - chemical synthesis</topic><topic>Stearates - chemistry</topic><topic>Stearates - pharmacology</topic><topic>Stearic Acids - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Azmat Ali</creatorcontrib><creatorcontrib>Alanazi, Amer M</creatorcontrib><creatorcontrib>Jabeen, Mumtaz</creatorcontrib><creatorcontrib>Chauhan, Arun</creatorcontrib><creatorcontrib>Abdelhameed, Ali Sabir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Azmat Ali</au><au>Alanazi, Amer M</au><au>Jabeen, Mumtaz</au><au>Chauhan, Arun</au><au>Abdelhameed, Ali Sabir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2013-06</date><risdate>2013</risdate><volume>33</volume><issue>6</issue><spage>2517</spage><epage>2524</epage><pages>2517-2524</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Chemical synthesis and characterization of a lipophilic ester conjugate, propofol stearate and evaluation of its anticancer efficacy on human breast cancer cell lines MDA-MB-361, MCF-7 and MDA-MB-231.
The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its anticancer potential was evaluated on the basis of growth inhibition, cancer cell adhesion and migration and apoptosis induction.
Propofol stearate exhibited significant (p<0.05) growth inhibition of breast cancer cells in a concentration-dependent manner. MDA-MB-231 cells showed highest susceptibility towards the inhibitory effect of the conjugate. Moreover, treatment of MDA-MB-231 cancer cells with 25 μM propofol stearate potentially suppressed their adhesion (~34%) and migration (~41%), and induced apoptosis (~25%).
Exogenously-applied stearic acid as an ester derivative, inhibits the growth of human breast cancer cells and shows a beneficial role in the treatment of breast cancer, in vitro.</abstract><cop>Greece</cop><pmid>23749903</pmid><tpages>8</tpages></addata></record> |
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| ispartof | Anticancer research, 2013-06, Vol.33 (6), p.2517-2524 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Breast Neoplasms - drug therapy Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Drug Design Esters - chemistry Female Humans Propofol - analogs & derivatives Propofol - chemical synthesis Propofol - chemistry Propofol - pharmacology Stearates - chemical synthesis Stearates - chemistry Stearates - pharmacology Stearic Acids - chemistry |
| title | Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate |
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