Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases

T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T‐cell‐mediated cutaneous diseases. Skin‐seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T‐cell‐media...

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Veröffentlicht in:	Experimental dermatology 2013-07, Vol.22 (7), p.439-442
Hauptverfasser:	Ferran, Marta, Romeu, Ester R., Rincón, Catalina, Sagristà, Marc, Giménez Arnau, Ana M., Celada, Antonio, Pujol, Ramon M., Holló, Péter, Jókai, Hajnalka, Santamaria-BabÍ, Luis F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, T-Lymphocyte - metabolism associated antigen biomarker Biomarkers - metabolism cutaneous lymphocyte Humans Immunologic Memory Inflammation Membrane Glycoproteins - metabolism Mice Phenotype Psoriasis - immunology Skin Diseases - immunology Skin Neoplasms - immunology skin-homing T lymphocyte T-Lymphocytes - cytology
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Zusammenfassung:	T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T‐cell‐mediated cutaneous diseases. Skin‐seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T‐cell‐mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T‐cell‐mediated skin diseases.
ISSN:	0906-6705 1600-0625
DOI:	10.1111/exd.12154