Focus issue: From genomic mutations to oncogenic pathways

This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and de...

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Veröffentlicht in:Science signaling 2013-03, Vol.6 (268), p.eg3-eg3
1. Verfasser: Gough, Nancy R
Format: Artikel
Sprache:eng
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Zusammenfassung:This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and dependencies on different signaling pathways for survival or for metastatic potential. New tools and technologies for genomic- or systems-level analysis, as well as conventional biochemistry and cell biology approaches, are revealing how signaling pathways contribute to cancer development, cancer evolution, and drug resistance.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.2004149