Lipopolysaccharides: Structural Principles and Biologic Activities

Structural principles of the three regions of the lipopolysaccharide molecule are briefly discussed. One of the recently available, chemically synthesized lipid A analogues has been tested for biologic activities. The preparation was found to be toxic, pyrogenic, and mitogenic. The amounts, however,...

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Veröffentlicht in:	Reviews of infectious diseases 1984-07, Vol.6 (4), p.428-431
Hauptverfasser:	O. Lüderitz, K. Tanamoto, Galanos, C., G. R. Mc Kenzie, Brade, H., Zähringer, U., E. Th. Rietschel, S. Kusumoto, Shiba, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Chemical synthesis Endotoxins Fatty acids Lipid A - immunology Lipid A - toxicity Lipids Lipopolysaccharides Lipopolysaccharides - analysis Mice Mitogens - pharmacology Molecular structure Molecules Oligosaccharides Pyrogens - toxicity Rabbits Salmonella Structure-Activity Relationship Symposium I. Structural Aspects of Lipid A
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Beschreibung
Zusammenfassung:	Structural principles of the three regions of the lipopolysaccharide molecule are briefly discussed. One of the recently available, chemically synthesized lipid A analogues has been tested for biologic activities. The preparation was found to be toxic, pyrogenic, and mitogenic. The amounts, however, needed for expression of effects similar to those of lipid A were about 500 times higher. These investigations are aimed at verifying the proposed structure of lipid A and at evaluating structure-activity relationships.
ISSN:	0162-0886