A novel transforming gene in a human malignant melanoma cell line

A novel transforming gene in a human malignant melanoma cell line

Cellular transforming genes can be detected in human tumour by DNA-mediated transfection into NIH 3T3 mouse fibroblasts. The activated transforming genes have been, in most cases, members of the ras gene family, of which the most frequently found is the c-Ki-ras oncogene and least frequently the c-H...

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Veröffentlicht in:Nature (London) 1984-01, Vol.311 (5987), p.473-674
Hauptverfasser: Padua, R A, Barrass, N, Curie, G A
Format: Artikel
Sprache:eng
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Zusammenfassung:Cellular transforming genes can be detected in human tumour by DNA-mediated transfection into NIH 3T3 mouse fibroblasts. The activated transforming genes have been, in most cases, members of the ras gene family, of which the most frequently found is the c-Ki-ras oncogene and least frequently the c-Ha-ras gene. Here the authors describe the presence of transforming activity in the DNA from a human melanoma cell line which shows weak homology with members of the ras oncogene family.
ISSN:0028-0836