Effects of aflatoxin B1 on distribution of Fe, Cu, Zn, and Mn in rat tissues

Effects of injected aflatoxin b1 on the distribution of iron, copper, zinc, and manganese in rat tissues are examined. Preliminary evidence points to a complex effect involving not only a redistribution of the metals, but possibly some hormonal action as well. It remains to be determined whether the...

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Veröffentlicht in:	Bulletin of environmental contamination and toxicology 1977, Vol.17 (1), p.33-39
Hauptverfasser:	Doyle, J.J, Stearman, W.C. III, Norman, J.O, Petersen, H.D.V
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxins - pharmacology Animals Body Weight - drug effects Copper - metabolism Dimethyl Sulfoxide - pharmacology iron Iron - metabolism Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male manganese Manganese - metabolism Metals - metabolism Pancreas - drug effects Pancreas - metabolism Rats Spleen - drug effects Spleen - metabolism Trace Elements - metabolism Zinc - metabolism
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Zusammenfassung:	Effects of injected aflatoxin b1 on the distribution of iron, copper, zinc, and manganese in rat tissues are examined. Preliminary evidence points to a complex effect involving not only a redistribution of the metals, but possibly some hormonal action as well. It remains to be determined whether the redistribution of metals, especially the massive influx of iron into the livers, is the actual toxic factor in aflatoxicosis that leads to sickness and death.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/BF01685260