Mechanism of stigmasterol dealkylation in insect

Deuterated stigmasterols (10, 11 and 12) were chemically synthesized and fed to silk-worm larvae. GC-MS analysis of the metabolites, cholesterol (4) and desmosterol (6), indicates the migration of 25-hydrogen to C-24 position during stigmasterol dealkylation. 22,24(28)-Dienes(8a and 8b) were shown t...

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Veröffentlicht in:	Tetrahedron letters 1984, Vol.25 (14), p.1501-1504
Hauptverfasser:	Fujimoto, Yoshinori, Kimura, Miki, Takasu, Akihiro, Khalifa, Fathy A.M., Morisaki, Masuo, Ikekawa, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Bombycidae Bombyx mori Fundamental and applied biological sciences. Psychology Other biological molecules Terpenes, steroids. Hormones
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Beschreibung
Zusammenfassung:	Deuterated stigmasterols (10, 11 and 12) were chemically synthesized and fed to silk-worm larvae. GC-MS analysis of the metabolites, cholesterol (4) and desmosterol (6), indicates the migration of 25-hydrogen to C-24 position during stigmasterol dealkylation. 22,24(28)-Dienes(8a and 8b) were shown to be converted to 22,24-diene (5), desmosterol and cholesterol.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/S0040-4039(01)80197-0