Microsomal epoxidation of aldrin to dieldrin in rats

Microsomal epoxidation of aldrin to dieldrin in rats

Comparative studies on the conversion of aldrin to dieldrin are conducted in Vitro using liver microsomes obtained from rats, pretreated and not pretreated with sodium phenobarbital. Mixed-function oxidases system of rat hepatic microsomes is dramatically enhanced by induction with phenobarbital. A...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bulletin of environmental contamination and toxicology 1976-03, Vol.15 (3), p.324-329
Hauptverfasser: Ghiasuddin, S.M, Menzer, R.E
Format: Artikel
Sprache:eng
Schlagworte:
animal health
animal injuries
pesticides
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Comparative studies on the conversion of aldrin to dieldrin are conducted in Vitro using liver microsomes obtained from rats, pretreated and not pretreated with sodium phenobarbital. Mixed-function oxidases system of rat hepatic microsomes is dramatically enhanced by induction with phenobarbital. A maximum limit for the oxidation of aldrin to dieldrin in microsomes from uninduced rats is suggested. After induction, conversion is nearly quantitative.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF01812643