Phorbol esters as probes of the regulation of thyrotropin secretion

12-0-Tetradecanoylphorbol 13-acetate and thyrotropin releasing hormone were compared as thyrotropin secretagogues in cultured rat pituitary cells. The maximal secretion evoked by the former was only half that evoked by the latter. A23187 plus 12-0-tetradecanoylphorbol 13-acetate together produced as...

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Veröffentlicht in:	Biochemical and biophysical research communications 1984-11, Vol.125 (1), p.353-359
Hauptverfasser:	Koenig, Ronald J., Senator, David, Larsen, P. Reed
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Calcimycin - pharmacology Cycloheximide - pharmacology Dose-Response Relationship, Drug Exact sciences and technology Male Other techniques and industries Phorbol Esters - pharmacology Phorbols - pharmacology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Rats Rats, Inbred Strains Tetradecanoylphorbol Acetate - pharmacology Thyrotropin - metabolism Thyrotropin-Releasing Hormone - pharmacology Triiodothyronine - pharmacology
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Zusammenfassung:	12-0-Tetradecanoylphorbol 13-acetate and thyrotropin releasing hormone were compared as thyrotropin secretagogues in cultured rat pituitary cells. The maximal secretion evoked by the former was only half that evoked by the latter. A23187 plus 12-0-tetradecanoylphorbol 13-acetate together produced as large a response as thyrotropin releasing hormone. Triiodothyronine inhibited phorbol ester-induced thyrotropin secretion, and this inhibition required protein synthesis.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(84)80375-7