Delayed ethanol elimination from rat blood after treatment with thiram, tetramethylthiuram monosulfide, ziram, or cyanamide [Pesticides]

Therapy with the alcohol deterrent disulfiram (tetraethylthiuram disulfide, TETD) caused a delayed ethanol elimination from the blood of human subjects. The aim of the present study was to evaluate in an experiment with rats to which extent other dithiocarbamate-derivatives retard the elimination of ethanol. To this end the following compounds were tested: tetramethylthiuram disulfide (thiram, TMTD), tetramethylthiuram monosulfide (TMTM), bis(dimethyldithiocarbamato) zinc (ziram), (ethylene bis(dithiocarbamato)) zinc (zineb) and cyanamide (metabolized in the human organism to compounds of the dithiocarbamate type). Calcium cyanamide is used as fertilizer, all the other substances are used as fungicides or rubber accelerators. Human contact especially occurs at the workplace.