Effect of short-term administration of sex hormones on normal and autoimmune mice

Effect of short-term administration of sex hormones on normal and autoimmune mice

The effects of short-term administration (2 to 4 wk) of sex hormones on the immune system of normal (C57BL/6) and autoimmune (C57BL/6-lpr, C3H/lpr, B/W) strains of mice were investigated. Both estrogen (E sub(2)) and testosterone (Te) had significant effects on the numbers of T and B cells as well a...

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Veröffentlicht in:The Journal of immunology (1950) 1985-01, Vol.134 (1), p.204-210
Hauptverfasser: Ahmed, SA, Dauphinee, MJ, Talal, N
Format: Artikel
Sprache:eng
Schlagworte:
autoimmunity
estradiol
immune system
mice
sex hormones
testosterone
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Zusammenfassung:The effects of short-term administration (2 to 4 wk) of sex hormones on the immune system of normal (C57BL/6) and autoimmune (C57BL/6-lpr, C3H/lpr, B/W) strains of mice were investigated. Both estrogen (E sub(2)) and testosterone (Te) had significant effects on the numbers of T and B cells as well as on the density of cell surface antigens as demonstrated by flow cytometry. The relevance of these findings to differential sex susceptibility in autoimmune disease is discussed.
ISSN:0022-1767