Stereoselective Total Synthesis of Ieodomycins A and B and Revision of the NMR Spectroscopic Data of Ieodomycin B

Stereoselective Total Synthesis of Ieodomycins A and B and Revision of the NMR Spectroscopic Data of Ieodomycin B

Stereoselective total synthesis of antimicrobial marine metabolites ieodomycin A and B have been accomplished starting from commercially available 4-pentyn-1-ol featuring strategic application of the Negishi reaction, Kumada coupling, and Crimmins acetate aldol. This revises the proton NMR spectra o...

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Veröffentlicht in:Journal of organic chemistry 2013-07, Vol.78 (14), p.7274-7280
Hauptverfasser: Das, Sayantan, Goswami, Rajib Kumar
Format: Artikel
Sprache:eng
Schlagworte:
Fatty Acids, Unsaturated - chemical synthesis
Fatty Acids, Unsaturated - chemistry
Lactones - chemical synthesis
Lactones - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Pyrones - chemical synthesis
Pyrones - chemistry
Stereoisomerism
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Zusammenfassung:Stereoselective total synthesis of antimicrobial marine metabolites ieodomycin A and B have been accomplished starting from commercially available 4-pentyn-1-ol featuring strategic application of the Negishi reaction, Kumada coupling, and Crimmins acetate aldol. This revises the proton NMR spectra of ieodomycin B.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo400929m