Supramolecular Assemblies of Amphiphilic L-Proline Regulated by Compressed CO2 as a Recyclable Organocatalyst for the Asymmetric Aldol Reaction

Compressed CO2 triggers the formation of amphiphilic proline supramolecular assemblies in water, which catalyze the asymmetric aldol reaction without any additives. Compressed CO2 can dynamically regulate the size of the assemblies and subsequently the catalyst activity and selectivity. Furthermore, CO2 provides the merit of easy separation and purification, making the process sustainable and recyclable.