Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore
Exposure to combined suboptimal concentrations of 4β-phorbol 12-myristate 13-acetate and the calcium ionophore A23187 stimulates superoxide release from guinea pig neutrophils to rates ca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was lar...
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| Veröffentlicht in: | Biochem. Biophys. Res. Commun.; (United States) 1984-07, Vol.122 (2), p.734-739 |
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| container_title | Biochem. Biophys. Res. Commun.; (United States) |
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| creator | Robinson, John M. Badwey, John A. Karnovsky, Manfred L. Karnovsky, Morris J. |
| description | Exposure to combined suboptimal concentrations of 4β-phorbol 12-myristate 13-acetate and the calcium ionophore A23187 stimulates superoxide release from guinea pig neutrophils to rates
ca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was largely dependent upon the presence of calcium in the extracellular medium. The data are discussed in relation to recent reports concerning the interactions of phorbol-esters with cells and the mechanism of activation of superoxide release by neutrophils. |
| doi_str_mv | 10.1016/S0006-291X(84)80095-9 |
| format | Article |
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ca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was largely dependent upon the presence of calcium in the extracellular medium. The data are discussed in relation to recent reports concerning the interactions of phorbol-esters with cells and the mechanism of activation of superoxide release by neutrophils.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/S0006-291X(84)80095-9</identifier><identifier>PMID: 6087812</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ; ALKALINE EARTH METALS ; ANIMALS ; BIOCHEMISTRY ; BIOLOGICAL EFFECTS ; BIOLOGICAL MATERIALS ; BLOOD ; BLOOD CELLS ; BODY FLUIDS ; Calcimycin - pharmacology ; CALCIUM ; Calcium - pharmacology ; CARCINOGENS ; CHEMISTRY ; CLEARANCE ; Drug Synergism ; ELEMENTS ; ESTERS ; GUINEA PIGS ; Kinetics ; LEUKOCYTES ; Magnesium - pharmacology ; MAMMALS ; MATERIALS ; METABOLIC ACTIVATION ; METALS ; NEUTROPHILS ; Neutrophils - drug effects ; Neutrophils - metabolism ; ORGANIC COMPOUNDS ; PHORBOL ESTERS ; Phorbols - pharmacology ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADICALS ; RODENTS ; SUPEROXIDE RADICALS ; Superoxides - blood ; SYNERGISM ; Tetradecanoylphorbol Acetate - pharmacology ; VERTEBRATES</subject><ispartof>Biochem. Biophys. Res. Commun.; (United States), 1984-07, Vol.122 (2), p.734-739</ispartof><rights>1984 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-9660aad695f76bedd80cf03dd0134044fe191cd96d2926507be2b4b98d6c2b463</citedby><cites>FETCH-LOGICAL-c418t-9660aad695f76bedd80cf03dd0134044fe191cd96d2926507be2b4b98d6c2b463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-291X(84)80095-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6087812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5969971$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinson, John M.</creatorcontrib><creatorcontrib>Badwey, John A.</creatorcontrib><creatorcontrib>Karnovsky, Manfred L.</creatorcontrib><creatorcontrib>Karnovsky, Morris J.</creatorcontrib><creatorcontrib>Harvard Medical School, Boston, MA</creatorcontrib><title>Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore</title><title>Biochem. Biophys. Res. Commun.; (United States)</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Exposure to combined suboptimal concentrations of 4β-phorbol 12-myristate 13-acetate and the calcium ionophore A23187 stimulates superoxide release from guinea pig neutrophils to rates
ca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was largely dependent upon the presence of calcium in the extracellular medium. The data are discussed in relation to recent reports concerning the interactions of phorbol-esters with cells and the mechanism of activation of superoxide release by neutrophils.</description><subject>560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)</subject><subject>ALKALINE EARTH METALS</subject><subject>ANIMALS</subject><subject>BIOCHEMISTRY</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BODY FLUIDS</subject><subject>Calcimycin - pharmacology</subject><subject>CALCIUM</subject><subject>Calcium - pharmacology</subject><subject>CARCINOGENS</subject><subject>CHEMISTRY</subject><subject>CLEARANCE</subject><subject>Drug Synergism</subject><subject>ELEMENTS</subject><subject>ESTERS</subject><subject>GUINEA PIGS</subject><subject>Kinetics</subject><subject>LEUKOCYTES</subject><subject>Magnesium - pharmacology</subject><subject>MAMMALS</subject><subject>MATERIALS</subject><subject>METABOLIC ACTIVATION</subject><subject>METALS</subject><subject>NEUTROPHILS</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>ORGANIC COMPOUNDS</subject><subject>PHORBOL ESTERS</subject><subject>Phorbols - pharmacology</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADICALS</subject><subject>RODENTS</subject><subject>SUPEROXIDE RADICALS</subject><subject>Superoxides - blood</subject><subject>SYNERGISM</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>VERTEBRATES</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1q3DAURkVoSCfTPkJAdFGShZMrjyxb3ZQS8gcDWUwK3QlZus6oeCxXskPm7SPHQ7ZdSej7ru7hEHLG4JIBE1cbABBZLtmf84pfVACyyOQRWTCQkOUM-Cey-Kh8Jqcx_gVgjAt5Qk4EVGXF8gXRm7HH4F-dRRqwRR2R1nva4TgE329dG3_Qzb7D8Ozi4AzFpkEzROobqmm_9aH2LcU4YKC6s-nN6Na4cUed7_yU4xdy3Og24tfDuSS_b2-eru-z9ePdw_WvdWY4q4ZMCgFaWyGLphQ1WluBaWBlLbAVB84bZJIZK4XNZS4KKGvMa17LygqTLmK1JN_mf30CVdG4Ac3W-K5LvKqQQsqSpdL3udQH_29M3GrnosG21R36MSrGIU8qy1Qs5qIJPsaAjeqD2-mwVwzU5F-9-1eTXFVx9e5fyTR3dlgw1ju0H1MH4Sn_OeeYVLw4DBMpdgatCxOo9e4_G94AXVOV2w</recordid><startdate>19840731</startdate><enddate>19840731</enddate><creator>Robinson, John M.</creator><creator>Badwey, John A.</creator><creator>Karnovsky, Manfred L.</creator><creator>Karnovsky, Morris J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>OTOTI</scope></search><sort><creationdate>19840731</creationdate><title>Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore</title><author>Robinson, John M. ; Badwey, John A. ; Karnovsky, Manfred L. ; Karnovsky, Morris J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-9660aad695f76bedd80cf03dd0134044fe191cd96d2926507be2b4b98d6c2b463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)</topic><topic>ALKALINE EARTH METALS</topic><topic>ANIMALS</topic><topic>BIOCHEMISTRY</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>BODY FLUIDS</topic><topic>Calcimycin - pharmacology</topic><topic>CALCIUM</topic><topic>Calcium - pharmacology</topic><topic>CARCINOGENS</topic><topic>CHEMISTRY</topic><topic>CLEARANCE</topic><topic>Drug Synergism</topic><topic>ELEMENTS</topic><topic>ESTERS</topic><topic>GUINEA PIGS</topic><topic>Kinetics</topic><topic>LEUKOCYTES</topic><topic>Magnesium - pharmacology</topic><topic>MAMMALS</topic><topic>MATERIALS</topic><topic>METABOLIC ACTIVATION</topic><topic>METALS</topic><topic>NEUTROPHILS</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - metabolism</topic><topic>ORGANIC COMPOUNDS</topic><topic>PHORBOL ESTERS</topic><topic>Phorbols - pharmacology</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADICALS</topic><topic>RODENTS</topic><topic>SUPEROXIDE RADICALS</topic><topic>Superoxides - blood</topic><topic>SYNERGISM</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, John M.</creatorcontrib><creatorcontrib>Badwey, John A.</creatorcontrib><creatorcontrib>Karnovsky, Manfred L.</creatorcontrib><creatorcontrib>Karnovsky, Morris J.</creatorcontrib><creatorcontrib>Harvard Medical School, Boston, MA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Biochem. Biophys. Res. 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ca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was largely dependent upon the presence of calcium in the extracellular medium. The data are discussed in relation to recent reports concerning the interactions of phorbol-esters with cells and the mechanism of activation of superoxide release by neutrophils.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6087812</pmid><doi>10.1016/S0006-291X(84)80095-9</doi><tpages>6</tpages></addata></record> |
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| subjects | 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ALKALINE EARTH METALS ANIMALS BIOCHEMISTRY BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS Calcimycin - pharmacology CALCIUM Calcium - pharmacology CARCINOGENS CHEMISTRY CLEARANCE Drug Synergism ELEMENTS ESTERS GUINEA PIGS Kinetics LEUKOCYTES Magnesium - pharmacology MAMMALS MATERIALS METABOLIC ACTIVATION METALS NEUTROPHILS Neutrophils - drug effects Neutrophils - metabolism ORGANIC COMPOUNDS PHORBOL ESTERS Phorbols - pharmacology RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADICALS RODENTS SUPEROXIDE RADICALS Superoxides - blood SYNERGISM Tetradecanoylphorbol Acetate - pharmacology VERTEBRATES |
| title | Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore |
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