Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore

Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore

Exposure to combined suboptimal concentrations of 4β-phorbol 12-myristate 13-acetate and the calcium ionophore A23187 stimulates superoxide release from guinea pig neutrophils to rates ca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was lar...

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Veröffentlicht in:Biochem. Biophys. Res. Commun.; (United States) 1984-07, Vol.122 (2), p.734-739
Hauptverfasser: Robinson, John M., Badwey, John A., Karnovsky, Manfred L., Karnovsky, Morris J.
Format: Artikel
Sprache:eng
Schlagworte:
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
ALKALINE EARTH METALS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
Calcimycin - pharmacology
CALCIUM
Calcium - pharmacology
CARCINOGENS
CHEMISTRY
CLEARANCE
Drug Synergism
ELEMENTS
ESTERS
GUINEA PIGS
Kinetics
LEUKOCYTES
Magnesium - pharmacology
MAMMALS
MATERIALS
METABOLIC ACTIVATION
METALS
NEUTROPHILS
Neutrophils - drug effects
Neutrophils - metabolism
ORGANIC COMPOUNDS
PHORBOL ESTERS
Phorbols - pharmacology
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RADICALS
RODENTS
SUPEROXIDE RADICALS
Superoxides - blood
SYNERGISM
Tetradecanoylphorbol Acetate - pharmacology
VERTEBRATES
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Zusammenfassung:Exposure to combined suboptimal concentrations of 4β-phorbol 12-myristate 13-acetate and the calcium ionophore A23187 stimulates superoxide release from guinea pig neutrophils to rates ca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was largely dependent upon the presence of calcium in the extracellular medium. The data are discussed in relation to recent reports concerning the interactions of phorbol-esters with cells and the mechanism of activation of superoxide release by neutrophils.
ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(84)80095-9