OXIDATION OF 1, 3-DIMETHYL DERIVATIVES OF PYRIMIDINE BASES WITH m-CHLOROPERBENZOIC ACID

Oxidation of 1, 3-dimethylthymine (1), 1, 3-dimethyluracil (2), and 5-fluoro-1, 3-dimethyluracil (3) with m-chloroperbenzoic acid were investigated. 1 gave the cis diol 5, 6-dihydrothymine derivative (4) stereoselectively. Its stereostructure was definitely determined by an X-ray analysis. 2 afforde...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1984/05/25, Vol.32(5), pp.2056-2058
Hauptverfasser:	Harayama, Takashi, Kotoji, Kayoko, Yoneda, Fumio, Taga, Tooru, Osaki, Kenji, Nagamatsu, Tomohisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry cis 5, 6-dihydroxy-5, 6-dihydroxy-5, 6-dihydrothymine Condensed matter: structure, mechanical and thermal properties Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Organic chemistry Organic compounds Physics Preparations and properties Structure of solids and liquids crystallography Structure of specific crystalline solids
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Zusammenfassung:	Oxidation of 1, 3-dimethylthymine (1), 1, 3-dimethyluracil (2), and 5-fluoro-1, 3-dimethyluracil (3) with m-chloroperbenzoic acid were investigated. 1 gave the cis diol 5, 6-dihydrothymine derivative (4) stereoselectively. Its stereostructure was definitely determined by an X-ray analysis. 2 afforded 7, 8, and 9, and 3 afforded 8.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.32.2056