The kindling model of epilepsy

Kindling is a lasting change in brain function that results from repeated focal stimulation and leads to the development of a predisposition to epileptiform convulsions. Although the neural basis of kindling is known to be very long-lasting, transynaptic, pathway-specific and widespread, a satisfact...

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Veröffentlicht in:Trends in Neurosciences 1983, Vol.6 (7), p.275-279
1. Verfasser: Goddard, Graham V.
Format: Artikel
Sprache:eng
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Zusammenfassung:Kindling is a lasting change in brain function that results from repeated focal stimulation and leads to the development of a predisposition to epileptiform convulsions. Although the neural basis of kindling is known to be very long-lasting, transynaptic, pathway-specific and widespread, a satisfactory explanation has not yet been provided. As a model of epilepsy, kindling provides a source of clinical hypotheses, particularly with respect to the progression of epileptic symptomatology due to a number of etiologies, the development of post-traumatic seizure disorders and the question of prophylactic anticonvulsant treatment for a limited time after head injury.
ISSN:0166-2236
1878-108X
DOI:10.1016/0166-2236(83)90118-2