The kindling model of epilepsy
Kindling is a lasting change in brain function that results from repeated focal stimulation and leads to the development of a predisposition to epileptiform convulsions. Although the neural basis of kindling is known to be very long-lasting, transynaptic, pathway-specific and widespread, a satisfact...
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Veröffentlicht in: | Trends in Neurosciences 1983, Vol.6 (7), p.275-279 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Kindling is a lasting change in brain function that results from repeated focal stimulation and leads to the development of a predisposition to epileptiform convulsions. Although the neural basis of kindling is known to be very long-lasting, transynaptic, pathway-specific and widespread, a satisfactory explanation has not yet been provided. As a model of epilepsy, kindling provides a source of clinical hypotheses, particularly with respect to the progression of epileptic symptomatology due to a number of etiologies, the development of post-traumatic seizure disorders and the question of prophylactic anticonvulsant treatment for a limited time after head injury. |
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ISSN: | 0166-2236 1878-108X |
DOI: | 10.1016/0166-2236(83)90118-2 |