PolyNaSS grafting on titanium surfaces enhances osteoblast differentiation and inhibits Staphylococcus aureus adhesion

Titanium surface modifications to simultaneously prevent bacterial adhesion but promote bone-cell functions could be highly beneficial for improving implant osseointegration. In the present in vitro study, the effect of sulfonate groups on titanium surfaces was investigated with respect to both S. a...

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Veröffentlicht in:	Journal of materials science. Materials in medicine 2013-07, Vol.24 (7), p.1745-1754
Hauptverfasser:	Alcheikh, A., Pavon-Djavid, G., Helary, G., Petite, H., Migonney, V., Anagnostou, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Adhesion - drug effects Biofilms Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Cell Differentiation - drug effects Cells, Cultured Ceramics Chemistry and Materials Science Coated Materials, Biocompatible - chemical synthesis Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Composites Embryo, Mammalian Glass Kinetics Materials Science Materials Testing Medical sciences Microbial Sensitivity Tests Natural Materials Orthopedics Osseointegration - drug effects Osteoblasts - drug effects Osteoblasts - physiology Osteogenesis - drug effects Polymer Sciences Polymers - chemical synthesis Polymers - chemistry Polymers - pharmacology Polystyrenes - chemical synthesis Polystyrenes - chemistry Polystyrenes - pharmacology Rats Rats, Wistar Regenerative Medicine/Tissue Engineering Sodium - chemistry Sodium - pharmacology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Sulfonium Compounds - chemical synthesis Sulfonium Compounds - chemistry Sulfonium Compounds - pharmacology Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films Tissue engineering Titanium Titanium - chemistry Titanium - pharmacology Transplants & implants
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Zusammenfassung:	Titanium surface modifications to simultaneously prevent bacterial adhesion but promote bone-cell functions could be highly beneficial for improving implant osseointegration. In the present in vitro study, the effect of sulfonate groups on titanium surfaces was investigated with respect to both S. aureus adhesion and osteoblast functions pertinent to new bone formation. Commercial pure titanium (cpTi) squares were oxydized (Tiox), grafted with poly(sodium styrene sulfonate) groups (Tigraft) by covalent bonding using radical polymerization, and were characterized by infrared spectroscopy (HATR-FTIR) and colorimetry. Bacterial adhesion study showed that Tigraft exhibited high inhibition of S. aureus adhesion S at levels >90 %, when compared to cpTi ( P
ISSN:	0957-4530 1573-4838
DOI:	10.1007/s10856-013-4932-3