Effect of Regenerative Injection Therapy on Function and Pain in Patients with Knee Osteoarthritis: A Randomized Crossover Study

Objective.  We assessed the effectiveness of regenerative injection therapy (RIT) to relieve pain and restore function in patients with knee osteoarthritis. Design.  Crossover study where participants were randomly assigned to receive exercise therapy for 32 weeks in combination with RIT on weeks 0,...

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Veröffentlicht in:Pain medicine (Malden, Mass.) Mass.), 2012-08, Vol.13 (8), p.990-999
Hauptverfasser: Dumais, Richard, Benoit, Catherine, Dumais, Alexis, Babin, Lise, Bordage, Rachel, de Arcos, Claire, Allard, Jacques, Bélanger, Mathieu
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Sprache:eng
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Zusammenfassung:Objective.  We assessed the effectiveness of regenerative injection therapy (RIT) to relieve pain and restore function in patients with knee osteoarthritis. Design.  Crossover study where participants were randomly assigned to receive exercise therapy for 32 weeks in combination with RIT on weeks 0, 4, 8, and 12 or RIT on weeks 20, 24, 28, and 32. Patients.  Thirty‐six patients with chronic knee osteoarthritis. Interventions.  RIT, which is made up of injections of 1 cc of 15% dextrose 0.6% lidocaine in the collateral ligaments and a 5 cc injection of 20% dextrose 0.5% lidocaine inside the knee joint. Outcome Measures.  The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index of severity of osteoarthrosis symptoms (WOMAC) score (range: 0–96). Results.  Following 16 weeks of follow‐up, the participants assigned to RIT presented a significant reduction of their osteoarthritis symptoms (mean ± standard deviation: −21.8 ± 12.5, P 
ISSN:1526-2375
1526-4637
DOI:10.1111/j.1526-4637.2012.01422.x