The Effect of Protamine on Serum Complement Activity in Aminonucleoside Nephropathy

FUKUDA, K., SEINO, J., SAITO, T., YAMAKAGE, K., KYOGOKU, Y., KUROSAWA, K., SATO, H., FURUYAMA, T. and YOSHINAGA, K. The Effect of Protamine on Serum Complement Activity in Aminonucleoside Nephropathy. Tohoku J. exp. Med., 1984, 143 (3), 315-318-Combined administration of protamine sulfate (Ps) and a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Tohoku Journal of Experimental Medicine 1984, Vol.143(3), pp.315-318
Hauptverfasser: FUKUDA, KAZUO, SEINO, JIN, SAITO, TAKAO, YAMAKAGE, KEI, KYOGOKU, YOSHIO, KUROSAWA, KOSEI, SATO, HIROSHI, FURUYAMA, TAKASHI, YOSHINAGA, KAORU
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:FUKUDA, K., SEINO, J., SAITO, T., YAMAKAGE, K., KYOGOKU, Y., KUROSAWA, K., SATO, H., FURUYAMA, T. and YOSHINAGA, K. The Effect of Protamine on Serum Complement Activity in Aminonucleoside Nephropathy. Tohoku J. exp. Med., 1984, 143 (3), 315-318-Combined administration of protamine sulfate (Ps) and aminonucleoside (AN) to rats causes severe nephrotic syndrome and, histologically, focal glomerular sclerosis. These changes are more distinct than those produced by AN alone. While the exact mechanism of Ps acting on AN nephropathy is not known, marked hypocomplementemia was observed regularly after the Ps+AN injection, suggeting that complement is activated and consumed in the kidney. It is suggested that complement may play an important role in AN+Ps nephropathy.
ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.143.315