Evaluation of the beta -carboline ZK 93426 as a benzodiazepine receptor antagonist

Evaluation of the beta -carboline ZK 93426 as a benzodiazepine receptor antagonist

The authors describe here biochemical and pharmacological effects of the beta -carboline ZK 93426, a new and potent benzodiazepine (BZ) receptor antagonist. ZK 93426 was compared with Ro 15-1788 and CGS 8216, two compounds previously described as BZ receptor antagonists. The finding with ZK 93426 su...

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Veröffentlicht in:Psychopharmacology 1984-01, Vol.83 (3), p.249-256
Hauptverfasser: Jensen, L H, Petersen, EN, Braestrup, C, honore, T, Kehr, W, Stephens, D N, Schneider, H, Seidelmann, D, Schmiechen, R
Format: Artikel
Sprache:eng
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Zusammenfassung:The authors describe here biochemical and pharmacological effects of the beta -carboline ZK 93426, a new and potent benzodiazepine (BZ) receptor antagonist. ZK 93426 was compared with Ro 15-1788 and CGS 8216, two compounds previously described as BZ receptor antagonists. The finding with ZK 93426 suggests that BZ receptor ligands may possess differential efficacy at BZ receptor subtypes.
ISSN:0033-3158
DOI:10.1007/BF00464789