Pronociceptive changes in the activity of rostroventromedial medulla (RVM) pain modulatory cells in the streptozotocin-diabetic rat

Highlights • The spontaneous activity of RVM ON-like cells is increased in STZ-diabetic rat. • The spontaneous activity of RVM OFF-like cells is decreased in STZ-diabetic rat. • The STZ-diabetic rats present decreased numbers of active RVM OFF-like cells. • Descending facilitation from the RVM concu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2013-07, Vol.96, p.39-44
Hauptverfasser:	Silva, M, Amorim, D, Almeida, A, Tavares, I, Pinto-Ribeiro, F, Morgado, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Descending pain modulation Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - diagnostic imaging Diabetic neuropathic pain Diabetic Neuropathies - etiology Diabetic Neuropathies - metabolism Disease Models, Animal Male Neuralgia - etiology Neuralgia - metabolism Neuralgia - physiopathology Neurology Neuronal activity Neurons - metabolism Nociception Pain Measurement - methods Rats Rats, Wistar RVM Streptozocin STZ-diabetic rat Synaptic Transmission - physiology Ultrasonography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • The spontaneous activity of RVM ON-like cells is increased in STZ-diabetic rat. • The spontaneous activity of RVM OFF-like cells is decreased in STZ-diabetic rat. • The STZ-diabetic rats present decreased numbers of active RVM OFF-like cells. • Descending facilitation from the RVM concurs to diabetic neuropathic pain. • Loss of descending pain inhibition from the RVM concurs to diabetic neuropathic pain.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2013.04.008