The role of complement in trauma and fracture healing

The role of complement in trauma and fracture healing

Highlights • We outline less known roles of complement after trauma and during fracture healing. • Complement intensively crosstalks with the coagulation, apoptosis and TLR system. • Complement affects tissue regeneration after fracture and bone turnover. • Osteoblasts and osteoclast are involved in...

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Veröffentlicht in:Seminars in immunology 2013-02, Vol.25 (1), p.73-78
Hauptverfasser: Huber-Lang, Markus, Kovtun, Anna, Ignatius, Anita
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Apoptosis
Blood Coagulation
Bone
Complement
Complement System Proteins - physiology
Fracture
Fracture Healing - immunology
Humans
Immunity, Innate
Osteogenesis - immunology
Receptors, Pattern Recognition - immunology
Regeneration
Trauma
Wounds and Injuries - immunology
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Beschreibung
Zusammenfassung:Highlights • We outline less known roles of complement after trauma and during fracture healing. • Complement intensively crosstalks with the coagulation, apoptosis and TLR system. • Complement affects tissue regeneration after fracture and bone turnover. • Osteoblasts and osteoclast are involved in local complement activation and response.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2013.05.006