IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects

Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular in...

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Veröffentlicht in:	Immunology letters 2013-05, Vol.152 (2), p.104-108
Hauptverfasser:	Inanir, Ahmet, Yigit, Serbulent, Tekcan, Akın, Tural, Sengul, Kismali, Gorkem
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Arthritis, Rheumatoid - genetics Female Gene Frequency Genetic Markers Genetic Predisposition to Disease Genotype Humans Interleukin-4 - genetics Interleukin-4 gene (IL-4) Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Methylenetetrahydrofolate reductase gene (MTHFR) Middle Aged Minisatellite Repeats - genetics Polymorphism Polymorphism, Single Nucleotide Rheumatiod arthritis Risk Factors Turkey
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Zusammenfassung:	Highlights • Significantly association found IL-4 gene 70 bp VNTR polymorphism and MTHFR C677T polymorphism with development of RA. • MTHFR / IL-4 CCP2 P2 combine genotype was estimated to have protective effect against RA. • We found that there was a difference between MTHFR genotypes and ocular involvement in patients with RA.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2013.05.004