Regulatory T cells, dendritic cells and neutrophils in patients with renal cell carcinoma

Highlights • Patients with renal cell carcinoma have more dendritic cells in the blood than controls. • Percentage of plasmacytoid dendritic cells in tumors is higher in the early stages. • Neutrophils comprise bigger portion of tumor infiltrating leukocytes in the late stages. • Patients with renal...

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Veröffentlicht in:	Immunology letters 2013-05, Vol.152 (2), p.144-150
Hauptverfasser:	Minárik, Ivo, Lašťovička, Jan, Budinský, Vít, Kayserová, Jana, Špíšek, Radek, Jarolím, Ladislav, Fialová, Anna, Babjuk, Marek, Bartůňková, Jiřina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Allergy and Immunology Antigens, CD - metabolism Carcinoma, Renal Cell - immunology CD83 Antigen Dendritic cells Dendritic Cells - immunology Female Humans Immunoglobulins - metabolism Kidney Neoplasms - immunology Leukocyte Common Antigens - metabolism Lymphocyte Activation - immunology Lymphocyte Count Male Membrane Glycoproteins - metabolism Middle Aged Myeloid Cells - immunology Neoplasm Staging Neutrophils Neutrophils - immunology Regulatory T cells Renal cell carcinoma T-Lymphocytes, Regulatory - immunology Tumor infiltration Tumor Microenvironment - immunology
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Zusammenfassung:	Highlights • Patients with renal cell carcinoma have more dendritic cells in the blood than controls. • Percentage of plasmacytoid dendritic cells in tumors is higher in the early stages. • Neutrophils comprise bigger portion of tumor infiltrating leukocytes in the late stages. • Patients with renal cancer have more regulatory T lymphocytes in the blood than healthy controls. • Regulatory T lymphocytes accumulate in tumor tissue regardless the disease stage.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2013.05.010