Copper-Catalyzed N‑Methylation of Amides and O‑Methylation of Carboxylic Acids by Using Peroxides as the Methylating Reagents

Copper-Catalyzed N‑Methylation of Amides and O‑Methylation of Carboxylic Acids by Using Peroxides as the Methylating Reagents

The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters. Tentative mechanistic studies suggest that this reaction is l...

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Veröffentlicht in:Organic letters 2013-07, Vol.15 (13), p.3326-3329
Hauptverfasser: Xia, Qinqin, Liu, Xiaolong, Zhang, Yuejiao, Chen, Chao, Chen, Wanzhi
Format: Artikel
Sprache:eng
Schlagworte:
Amides - chemistry
Carboxylic Acids - chemistry
Catalysis
Copper - chemistry
Indicators and Reagents - chemistry
Methylation
Molecular Structure
Peroxides - chemistry
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Zusammenfassung:The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol401362k