ATRP synthesis of poly(2-(methacryloyloxy)ethyl choline phosphate): a multivalent universal biomembrane adhesive

A new monomer, 2-(methacryloyloxy)ethyl choline phosphate, and its direct polymerization into a polyvalent choline phosphate are described, providing a universal biomembrane adhesive exhibiting rapid, strong attachment to any mammalian cell membrane and fast internalization, properties of great valu...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (61), p.6831-6833
Hauptverfasser:	Yu, Xifei, Yang, Xiaoqiang, Horte, Sonja, Kizhakkedathu, Jayachandran N, Brooks, Donald E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesives - chemistry Animals Cell Membrane - chemistry CHO Cells Cricetulus Erythrocyte Aggregation Erythrocytes - chemistry Humans Molecular Structure Phosphorylcholine - analogs & derivatives Phosphorylcholine - chemical synthesis Phosphorylcholine - chemistry Polymerization Polymethacrylic Acids - chemical synthesis Polymethacrylic Acids - chemistry
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Beschreibung
Zusammenfassung:	A new monomer, 2-(methacryloyloxy)ethyl choline phosphate, and its direct polymerization into a polyvalent choline phosphate are described, providing a universal biomembrane adhesive exhibiting rapid, strong attachment to any mammalian cell membrane and fast internalization, properties of great value in applications such as tissue engineering and drug delivery.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c3cc41895b