Evaluation of the genotoxicity of lac dye

Red lac dye, a by-product of the shellac industry, has the potential for use in foods, drugs and cosmetics as a colouring agent. As part of a series of tests of the suitability of lac dye for this purpose an evaluation of its genotoxicity was carried out. Lac dye was non-mutagenic in Ames tests usin...

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Veröffentlicht in:	Food and chemical toxicology 1984-01, Vol.22 (8), p.677-679
Hauptverfasser:	Banerjee, T.S., Bhaumik, G., Yu, C.-L., Swaminathan, B., Giri, A.K., Srivastava, S., Bhattacharjee, S.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azo Compounds - toxicity Biological and medical sciences Bone Marrow - drug effects Chemical mutagenesis Chromosomes - drug effects Coloring Agents - toxicity Cricetinae Cricetulus Food Coloring Agents - toxicity In Vitro Techniques Lung - drug effects Medical sciences Mice Microsomes, Liver - metabolism Mutagenicity Tests Mutagens Rats Salmonella typhimurium Salmonella typhimurium - genetics Toxicology
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Beschreibung
Zusammenfassung:	Red lac dye, a by-product of the shellac industry, has the potential for use in foods, drugs and cosmetics as a colouring agent. As part of a series of tests of the suitability of lac dye for this purpose an evaluation of its genotoxicity was carried out. Lac dye was non-mutagenic in Ames tests using five strains of Salmonella typhimurium with or without metabolic activation. No cytotoxicity or mutagenicity was observed in Chinese hamster lung (V79) cells exposed to lac dye in vitro. A clastogenic effect was observed in the bone-marrow cells of mice that had been treated with lac dye ip or orally.
ISSN:	0278-6915 1873-6351
DOI:	10.1016/0278-6915(84)90278-3