T cell-dependent B cell activation

One paper, among many, on T-cell dependent B-cell activation, states the authors, is correct and has successfully withstood 9 years of work in many laboratories. Schimpl and Wecker (1975) clearly distinguish, already then, 3 phases in B cell responses: induction, proliferation and maturation, which...

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Veröffentlicht in:Immunological reviews 1984 (78), p.211-224
Hauptverfasser: COUTINHO, A, POBOR, G, PETTERSSON, S, LEANDERSSON, T, FORSGREN, S, PEREIRA, P, BANDEIRA, A, MARTINEZ, A. C
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container_end_page 224
container_issue 78
container_start_page 211
container_title Immunological reviews
container_volume
creator COUTINHO, A
POBOR, G
PETTERSSON, S
LEANDERSSON, T
FORSGREN, S
PEREIRA, P
BANDEIRA, A
MARTINEZ, A. C
description One paper, among many, on T-cell dependent B-cell activation, states the authors, is correct and has successfully withstood 9 years of work in many laboratories. Schimpl and Wecker (1975) clearly distinguish, already then, 3 phases in B cell responses: induction, proliferation and maturation, which are separately controlled. Moreover, they point out that only the inductive phase is selective as to clonal specificities, while growth and maturation are controlled by polyclonal (non-specific) ligands and cellular structures "other than specific Ig receptors".
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source Wiley Online Library Journals Frontfile Complete
subjects Analysis of the immune response. Humoral and cellular immunity
Biological and medical sciences
Cell interactions
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
title T cell-dependent B cell activation
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