T cell-dependent B cell activation

One paper, among many, on T-cell dependent B-cell activation, states the authors, is correct and has successfully withstood 9 years of work in many laboratories. Schimpl and Wecker (1975) clearly distinguish, already then, 3 phases in B cell responses: induction, proliferation and maturation, which are separately controlled. Moreover, they point out that only the inductive phase is selective as to clonal specificities, while growth and maturation are controlled by polyclonal (non-specific) ligands and cellular structures "other than specific Ig receptors".