Total synthesis of 1 alpha ,25(R)-dihydroxy vitamin D sub(3) 26,23(S)-lactone (calcitriol lactone), a natural metabolite of vitamin D sub(3)
The total synthesis of 1 alpha ,25(R)-dihydroxy-vitamin D sub(3) 26,23(S)-lactone (calcitriol lactone) and the 23R,25S diastereomer via a convergent approach utilizing an ene reaction for C20 and C23 functionalization and the HPLC comparison to the natural metabolite are described.
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Veröffentlicht in: | Journal of organic chemistry 1983-01, Vol.48, p.4433-4436 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | The total synthesis of 1 alpha ,25(R)-dihydroxy-vitamin D sub(3) 26,23(S)-lactone (calcitriol lactone) and the 23R,25S diastereomer via a convergent approach utilizing an ene reaction for C20 and C23 functionalization and the HPLC comparison to the natural metabolite are described. |
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ISSN: | 0022-3263 |