Total synthesis of 1 alpha ,25(R)-dihydroxy vitamin D sub(3) 26,23(S)-lactone (calcitriol lactone), a natural metabolite of vitamin D sub(3)

The total synthesis of 1 alpha ,25(R)-dihydroxy-vitamin D sub(3) 26,23(S)-lactone (calcitriol lactone) and the 23R,25S diastereomer via a convergent approach utilizing an ene reaction for C20 and C23 functionalization and the HPLC comparison to the natural metabolite are described.

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Veröffentlicht in:Journal of organic chemistry 1983-01, Vol.48, p.4433-4436
Hauptverfasser: Wovkulich, P M, Baggiolini, E G, Hennessy, B M, Uskokovic, M R, Mayer, E, Norman, A W
Format: Artikel
Sprache:eng
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Zusammenfassung:The total synthesis of 1 alpha ,25(R)-dihydroxy-vitamin D sub(3) 26,23(S)-lactone (calcitriol lactone) and the 23R,25S diastereomer via a convergent approach utilizing an ene reaction for C20 and C23 functionalization and the HPLC comparison to the natural metabolite are described.
ISSN:0022-3263