Adenovirus pneumonia on guinea pigs: An experimental reproduction of the disease

The recently described virus-induced pneumonia in guineapigs was experimentally reproducible in newborn animals, though not in preadult animals. Baby hamsters and newborn rats were also not susceptible to infection. 10 of 11 infected newborn guineapigs developed pathological changes identical with those found in spontaneous cases. The incubation period was from 5 to 10 days. The morphology of the virus, its intranuclear location, the course of the disease and the histopathological and ultra-structural changes strongly suggest that the virus is an adenovirus specific for guineapigs.