A-16686, A NEW ANTIBIOTIC FROM ACTINOPLANES: I. FERMENTATION, ISOLATION AND PRELIMINARY PHYSICO-CHEMICAL CHARACTERISTICS

A-16686, A NEW ANTIBIOTIC FROM ACTINOPLANES: I. FERMENTATION, ISOLATION AND PRELIMINARY PHYSICO-CHEMICAL CHARACTERISTICS

Actinoplanes sp. ATCC 33076 is a new strain that was found to produce an antibiotic, designated A-16686, which is a complex of three closely-related polypeptides containing chlorinated phenyl moieties and D-mannose. Both the complex and the single fractions possess a good activity against Gram-posit...

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Veröffentlicht in:Journal of antibiotics 1984, Vol.37(4), pp.309-317
Hauptverfasser: CAVALLERI, BRUNO, PAGANI, HERMES, VOLPE, GIANCARLO, SELVA, ENRICO, PARENTI, FRANCO
Format: Artikel
Sprache:eng
Schlagworte:
Actinomycetales - classification
Actinomycetales - growth & development
Actinoplanes
Amino Acids - analysis
Anti-Bacterial Agents - isolation & purification
antibiotic A-16686
Antibiotics
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry
Culture Media
Depsipeptides
Drug Evaluation, Preclinical
Fermentation
Fundamental and applied biological sciences. Psychology
Glycopeptides - isolation & purification
Glycopeptides - toxicity
Gram-Positive Bacteria - drug effects
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Microbial Sensitivity Tests
Microbiology
Peptides, Cyclic
Production of active biomolecules
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Beschreibung
Zusammenfassung:Actinoplanes sp. ATCC 33076 is a new strain that was found to produce an antibiotic, designated A-16686, which is a complex of three closely-related polypeptides containing chlorinated phenyl moieties and D-mannose. Both the complex and the single fractions possess a good activity against Gram-positive bacteria. A-16686 specifically inhibits the synthesis of the bacterial cell wall.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.37.309