Supersensitivity to the respiratory stimulatory effect of TRH in 5,7-dihydroxytryptamine-treated rats

Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine (5,7-DHT) have an elevated p aCO 2 and reduced minute ventilation when given 0.7% halothane in oxygen as adults. Serotonin content in the spinal cord of 5,7-DHT treated rats was undetectable and TRH content was reduced by 35%. The 5,...

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Veröffentlicht in:	Brain research 1984-04, Vol.298 (2), p.370-373
Hauptverfasser:	Mueller, R.A., Towle, A.C., Breese, G.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	5,7-dihydroxytryptamine 5,7-Dihydroxytryptamine - toxicity Animals Biological and medical sciences Brain Stem - drug effects Carbon Dioxide - blood Dihydroxytryptamines - toxicity Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology halothane Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Injections, Intraventricular Male Neural Pathways - drug effects Oxygen - blood Pargyline - pharmacology Rats Rats, Inbred Strains respiration Respiration - drug effects serotonin Serotonin - metabolism Spinal Cord - drug effects thyrotropin releasing hormone Thyrotropin-Releasing Hormone - metabolism Thyrotropin-Releasing Hormone - pharmacology Vertebrates: endocrinology
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Zusammenfassung:	Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine (5,7-DHT) have an elevated p aCO 2 and reduced minute ventilation when given 0.7% halothane in oxygen as adults. Serotonin content in the spinal cord of 5,7-DHT treated rats was undetectable and TRH content was reduced by 35%. The 5,7-DHT treated rats were supersensitive to the increase in minute ventilation and CO 2 sensitivity produced by intraventricular TRH. It is possible that the supersensitivity to exogenous TRH after neonatal 5,7-DHT treatment may be secondary to decreased availability of TRH in the CNS.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(84)91440-9