Lithium chloride and avoidance of novel places

In Exp I, 40 male hooded rats were exposed to a distinctive chamber (Chamber A, part of a 2-chamber apparatus) that was novel for half of the Ss but familiar for the other half. Each S was subsequently injected with lithium chloride or saline. In a test trial conducted 24 hrs later, all Ss were given a choice between Chamber A and Chamber B, which was novel for all Ss. The group made familiar with Chamber A and then given lithium showed a significant preference for that side or an avoidance of the novel side, a "spatial neophobia." Exp II, with 40 Ss, confirmed the spatial neophobia effect and demonstrated that it did not depend on the particular conditioning procedure used in the 1st experiment. The spatial neophobia effect was related to similar effects in the taste aversion literature and to the results of research on lithium-induced decreases in exploratory behavior. (30 ref)