Antiviral Activity of Interferon in Rats and the Effect of Immune Suppression

Primate Center TNO, P.O. Box 5815, 2280 HV Rijswijk, The Netherlands and 1 Medical Biological Laboratory TNO, Rijswijk, The Netherlands The antiviral effect of interferon was studied in a number of experimental virus infections in the rat. Interferon was shown to protect rats infected with pseudorab...

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Veröffentlicht in:	Journal of general virology 1984-02, Vol.65 (2), p.391-396
Hauptverfasser:	Schellekens, H, Vreede, E. Smiers-De, De Reus, A, Dijkema, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azathioprine - pharmacology Biological and medical sciences Cell Line Cyclophosphamide - pharmacology Cyclosporins - pharmacology Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Herpesvirus 1, Suid - drug effects Humans Immunosuppression Immunosuppressive Agents - pharmacology Interferons - therapeutic use L Cells (Cell Line) Microbiology Parainfluenza Virus 1, Human - drug effects Parainfluenza Virus 1, Human - immunology Prednisolone - pharmacology Pregnancy Rats Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Simplexvirus - drug effects Vaccinia virus - drug effects Vesicular stomatitis Indiana virus - drug effects Virology Virus Diseases - therapy
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Zusammenfassung:	Primate Center TNO, P.O. Box 5815, 2280 HV Rijswijk, The Netherlands and 1 Medical Biological Laboratory TNO, Rijswijk, The Netherlands The antiviral effect of interferon was studied in a number of experimental virus infections in the rat. Interferon was shown to protect rats infected with pseudorabies virus, herpes simplex virus or vesicular stomatitis virus. The antiviral activity was not inhibited by immune suppression induced by azothioprine, prednisolone or cyclosporin A treatment. Cyclophosphamide completely blocked the in vivo activity of interferon in rats. Keywords: rat interferon, pseudorabies, immune suppression Received 18 May 1983; accepted 17 October 1983.
ISSN:	0022-1317 1465-2099
DOI:	10.1099/0022-1317-65-2-391