T and B lymphocyte subsets in fenoprofen nephropathy
Renal failure due to combined acute interstitial nephritis and minimal-change glomerulopathy is reported in two patients after fenoprofen therapy. In the interstitial infiltrates, T lymphocytes predominated over B lymphocytes in a ratio of four to one. The majority of B lymphocytes present were IgE-...
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Veröffentlicht in: | The American journal of medicine 1983-07, Vol.75 (1), p.9-16 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Renal failure due to combined acute interstitial nephritis and minimal-change glomerulopathy is reported in two patients after fenoprofen therapy. In the interstitial infiltrates, T lymphocytes predominated over B lymphocytes in a ratio of four to one. The majority of B lymphocytes present were IgE-bearing cells. Among the T cells, the ratio of cytotoxic/suppressor cells to helper-inducer cells was three to one. Repeated renal biopsy in one patient after steroid-induced clinical remission demonstrated resolution of the inflammatory infiltrate and restoration of normal glomerular foot processes. The theoretic and practical implications of these findings are discussed. |
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ISSN: | 0002-9343 1555-7162 |
DOI: | 10.1016/0002-9343(83)91161-0 |