Development of human embryonic stem cell therapies for age-related macular degeneration

Highlights • Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults. Recent research for treating AMD has focused on replacing the retinal pigment epithelium (RPE), a monolayer of cells vital to photoreceptor cell health • Various methods are used to differentiate...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2013-07, Vol.36 (7), p.385-395
Hauptverfasser:	Carr, Amanda-Jayne F, Smart, Matthew J.K, Ramsden, Conor M, Powner, Michael B, da Cruz, Lyndon, Coffey, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset age-related macular degeneration Animals cellular therapy Embryonic Stem Cells - transplantation human embryonic stem cells Humans induced pluripotent stem cells Macular degeneration Macular Degeneration - surgery Medical treatment Neurology Older people Retina retinal pigment epithelium Retinal Pigment Epithelium - cytology Stem Cell Transplantation - methods Stem cells transplantation
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Beschreibung
Zusammenfassung:	Highlights • Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults. Recent research for treating AMD has focused on replacing the retinal pigment epithelium (RPE), a monolayer of cells vital to photoreceptor cell health • Various methods are used to differentiate and purify RPE from human embryonic stem cells, and their efficacy as treatments are being tested in existing and forthcoming clinical trials.
ISSN:	0166-2236 1878-108X
DOI:	10.1016/j.tins.2013.03.006