Antioxidant effect of human adult adipose-derived stromal stem cells in alveolar epithelial cells undergoing stretch

Highlights • Cyclic stretch induces an oxidative damage on human alveolar cells in vitro. • Human adult adipose tissue-derived stromal cells (hADSCs) have an antioxidant effect in human alveolar cells undergo an injurious overstretch. • The stretch-induced nitrative damage on alveolar cells is atten...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2013-08, Vol.188 (1), p.1-8
Hauptverfasser:	Peñuelas, Oscar, Melo, Esther, Sánchez, Carolina, Sánchez, Isabel, Quinn, Kieran, Ferruelo, Antonio, Pérez-Vizcaíno, Francisco, Esteban, Andrés, Navajas, Daniel, Nin, Nicolás, Lorente, José A, Farré, Ramón
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury Adipose Tissue - cytology Adipose Tissue - metabolism Adult Adult Stem Cells - metabolism Cells, Cultured Cyclic stretch Human adipose-derived stromal stem cells Humans Medical Education Middle Aged Oxidative stress Oxidative Stress - physiology Pulmonary Alveoli - cytology Pulmonary Alveoli - metabolism Pulmonary/Respiratory Respiratory Mucosa - cytology Respiratory Mucosa - metabolism Stress, Mechanical Stromal Cells - metabolism Young Adult
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Zusammenfassung:	Highlights • Cyclic stretch induces an oxidative damage on human alveolar cells in vitro. • Human adult adipose tissue-derived stromal cells (hADSCs) have an antioxidant effect in human alveolar cells undergo an injurious overstretch. • The stretch-induced nitrative damage on alveolar cells is attenuated by hADSCs in vitro. • Human adipose tissue is a feasible resource for adult stromal cells isolation and provides a potential clinical benefit in acute lung injury.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2013.04.007