SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network
Highlights • SOX2 improves metastasis by promoting epithelial-to-mesenchymal transition through WNT/β-catenin. • We reveal activation and binding of SOX2 on promoter region of β-catenin. • SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3.
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| Veröffentlicht in: | Cancer letters 2013-08, Vol.336 (2), p.379-389 |
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| container_end_page | 389 |
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| container_issue | 2 |
| container_start_page | 379 |
| container_title | Cancer letters |
| container_volume | 336 |
| creator | Li, Xuefei Xu, Yingxi Chen, Yanan Chen, Si Jia, Xianpei Sun, Tongchao Liu, Yanhua Li, Xiru Xiang, Rong Li, Na |
| description | Highlights • SOX2 improves metastasis by promoting epithelial-to-mesenchymal transition through WNT/β-catenin. • We reveal activation and binding of SOX2 on promoter region of β-catenin. • SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3. |
| doi_str_mv | 10.1016/j.canlet.2013.03.027 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4b16102ed570e1a0188194196b46b8acb791caf08652ad3eae3f4457c17e788f3</citedby><cites>FETCH-LOGICAL-c417t-4b16102ed570e1a0188194196b46b8acb791caf08652ad3eae3f4457c17e788f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383513002577$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23545177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xuefei</creatorcontrib><creatorcontrib>Xu, Yingxi</creatorcontrib><creatorcontrib>Chen, Yanan</creatorcontrib><creatorcontrib>Chen, Si</creatorcontrib><creatorcontrib>Jia, Xianpei</creatorcontrib><creatorcontrib>Sun, Tongchao</creatorcontrib><creatorcontrib>Liu, Yanhua</creatorcontrib><creatorcontrib>Li, Xiru</creatorcontrib><creatorcontrib>Xiang, Rong</creatorcontrib><creatorcontrib>Li, Na</creatorcontrib><title>SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • SOX2 improves metastasis by promoting epithelial-to-mesenchymal transition through WNT/β-catenin. • We reveal activation and binding of SOX2 on promoter region of β-catenin. • SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3.</description><subject>Adaptor Proteins, Signal Transducing - biosynthesis</subject><subject>Animals</subject><subject>beta Catenin - metabolism</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell Line, Tumor</subject><subject>Dishevelled Proteins</subject><subject>EMT</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - biosynthesis</subject><subject>Male</subject><subject>MCF-7 Cells</subject><subject>Mice</subject><subject>Mice, Inbred NOD</subject><subject>Mice, SCID</subject><subject>Phosphoproteins - biosynthesis</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Signal Transduction</subject><subject>SOX2</subject><subject>SOXB1 Transcription Factors - genetics</subject><subject>SOXB1 Transcription Factors - metabolism</subject><subject>TGF-β1</subject><subject>Tumor metastasis</subject><subject>Wnt Proteins - metabolism</subject><subject>Xenograft Model Antitumor Assays</subject><subject>β-catenin</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2KFDEUhYMoTjv6BiJZuqme_FUltRFk8A8GZzEjugup1K2e9KSSNkmN9NZH8kF8JtP26MKNcCEEzrn3no-L0HNK1pTQ7my7tiZ4KGtGKF-TWkw-QCuqJGtkr8hDtCKciIYr3p6gJzlvCSGtkO1jdMJ4K1oq5Qp9v7r8wvAuxTkWyLgsc0x4hmJyLZfxsMe5uHnxpriwwbBz5Qa8M74psZkhQ7A3-9l4XJIJ2RUXA75zBifY_PbUb5zw54_XZz9_NNYUCC7g7DahWgKUbzHdPkWPJuMzPLt_T9Gnt2-uz983F5fvPpy_vmisoLI0YqAdJQzGVhKghlClaC9o3w2iG5Sxg-ypNRNRXcvMyMEAn4RopaUSpFITP0Uvj31r2q8L5KJnly14bwLEJWvKFSUVXN9VqThKbYo5J5j0LrnZpL2mRB_o660-0tcH-prUYrLaXtxPWIYZxr-mP7ir4NVRADXnnYOks3UVIYwugS16jO5_E_5tYL0Lzhp_C3vI27ikSrZm0Zlpoq8OF3A4AMoJYW3d4Bfj8K-x</recordid><startdate>20130819</startdate><enddate>20130819</enddate><creator>Li, Xuefei</creator><creator>Xu, Yingxi</creator><creator>Chen, Yanan</creator><creator>Chen, Si</creator><creator>Jia, Xianpei</creator><creator>Sun, Tongchao</creator><creator>Liu, Yanhua</creator><creator>Li, Xiru</creator><creator>Xiang, Rong</creator><creator>Li, Na</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130819</creationdate><title>SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network</title><author>Li, Xuefei ; Xu, Yingxi ; Chen, Yanan ; Chen, Si ; Jia, Xianpei ; Sun, Tongchao ; Liu, Yanhua ; Li, Xiru ; Xiang, Rong ; Li, Na</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4b16102ed570e1a0188194196b46b8acb791caf08652ad3eae3f4457c17e788f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adaptor Proteins, Signal Transducing - biosynthesis</topic><topic>Animals</topic><topic>beta Catenin - metabolism</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Line, Tumor</topic><topic>Dishevelled Proteins</topic><topic>EMT</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - biosynthesis</topic><topic>Male</topic><topic>MCF-7 Cells</topic><topic>Mice</topic><topic>Mice, Inbred NOD</topic><topic>Mice, SCID</topic><topic>Phosphoproteins - biosynthesis</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Signal Transduction</topic><topic>SOX2</topic><topic>SOXB1 Transcription Factors - genetics</topic><topic>SOXB1 Transcription Factors - metabolism</topic><topic>TGF-β1</topic><topic>Tumor metastasis</topic><topic>Wnt Proteins - metabolism</topic><topic>Xenograft Model Antitumor Assays</topic><topic>β-catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xuefei</creatorcontrib><creatorcontrib>Xu, Yingxi</creatorcontrib><creatorcontrib>Chen, Yanan</creatorcontrib><creatorcontrib>Chen, Si</creatorcontrib><creatorcontrib>Jia, Xianpei</creatorcontrib><creatorcontrib>Sun, Tongchao</creatorcontrib><creatorcontrib>Liu, Yanhua</creatorcontrib><creatorcontrib>Li, Xiru</creatorcontrib><creatorcontrib>Xiang, Rong</creatorcontrib><creatorcontrib>Li, Na</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xuefei</au><au>Xu, Yingxi</au><au>Chen, Yanan</au><au>Chen, Si</au><au>Jia, Xianpei</au><au>Sun, Tongchao</au><au>Liu, Yanhua</au><au>Li, Xiru</au><au>Xiang, Rong</au><au>Li, Na</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2013-08-19</date><risdate>2013</risdate><volume>336</volume><issue>2</issue><spage>379</spage><epage>389</epage><pages>379-389</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights • SOX2 improves metastasis by promoting epithelial-to-mesenchymal transition through WNT/β-catenin. • We reveal activation and binding of SOX2 on promoter region of β-catenin. • SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23545177</pmid><doi>10.1016/j.canlet.2013.03.027</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2013-08, Vol.336 (2), p.379-389 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptor Proteins, Signal Transducing - biosynthesis Animals beta Catenin - metabolism Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Dishevelled Proteins EMT Epithelial-Mesenchymal Transition Female Hematology, Oncology and Palliative Medicine Humans Intercellular Signaling Peptides and Proteins - biosynthesis Male MCF-7 Cells Mice Mice, Inbred NOD Mice, SCID Phosphoproteins - biosynthesis Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Signal Transduction SOX2 SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism TGF-β1 Tumor metastasis Wnt Proteins - metabolism Xenograft Model Antitumor Assays β-catenin |
| title | SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network |
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