SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network

Highlights • SOX2 improves metastasis by promoting epithelial-to-mesenchymal transition through WNT/β-catenin. • We reveal activation and binding of SOX2 on promoter region of β-catenin. • SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2013-08, Vol.336 (2), p.379-389
Hauptverfasser:	Li, Xuefei, Xu, Yingxi, Chen, Yanan, Chen, Si, Jia, Xianpei, Sun, Tongchao, Liu, Yanhua, Li, Xiru, Xiang, Rong, Li, Na
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - biosynthesis Animals beta Catenin - metabolism Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Dishevelled Proteins EMT Epithelial-Mesenchymal Transition Female Hematology, Oncology and Palliative Medicine Humans Intercellular Signaling Peptides and Proteins - biosynthesis Male MCF-7 Cells Mice Mice, Inbred NOD Mice, SCID Phosphoproteins - biosynthesis Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Signal Transduction SOX2 SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism TGF-β1 Tumor metastasis Wnt Proteins - metabolism Xenograft Model Antitumor Assays β-catenin
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Beschreibung
Zusammenfassung:	Highlights • SOX2 improves metastasis by promoting epithelial-to-mesenchymal transition through WNT/β-catenin. • We reveal activation and binding of SOX2 on promoter region of β-catenin. • SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.03.027