Transplacental Carcinogenesis with Radioactive Phosphorus: The Effects of Promoting Agents

1 In a previous experiment, using 32P as a potential transplacental carcinogen in rats, we found that the isotope caused life-span shortening, reduced growth and caused ante-dating of the time of the tumour occurrence. 2 Liver cell changes (nuclear atypia, variation in cell size) were noted and sugg...

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Veröffentlicht in:	Human & experimental toxicology 1984, Vol.3 (1), p.45-50
Hauptverfasser:	Berry, C.L., Nickols, C., Swettenham, K.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - metabolism Carcinogens - toxicity Chemical agents Dietary Fats - metabolism Dietary Fats - toxicity Female Maternal-Fetal Exchange Medical sciences Neoplasms, Radiation-Induced - embryology Phosphorus Radioisotopes - metabolism Phosphorus Radioisotopes - toxicity Pregnancy Rats Rats, Inbred Strains Tumors
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Beschreibung
Zusammenfassung:	1 In a previous experiment, using 32P as a potential transplacental carcinogen in rats, we found that the isotope caused life-span shortening, reduced growth and caused ante-dating of the time of the tumour occurrence. 2 Liver cell changes (nuclear atypia, variation in cell size) were noted and suggested liver cell damage, possible 'initiation'. 3 A phorbol ester (TPA) and a high fat/high protein diet were used as promoting agents on further transplacentally irradiated rats. 4 The results were identical to the previous experiment; no evidence of promotion was found.
ISSN:	0960-3271 0144-5952 1477-0903
DOI:	10.1177/0960327184003001061