Interaction of nogalamycin with chromatin

Interaction of nogalamycin with chromatin

Number of available nogalamycin binding sites in Sarcoma-180 chromatin is less than that present in Sarcoma-180 DNA. Gradual removal of proteins from chromatin by salt leads to increase in available drug binding sites, without appreciable alteration in binding affinity. Histones restrict the accessi...

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Veröffentlicht in:Chemico-biological interactions 1983-01, Vol.46 (3), p.347-352
Hauptverfasser: Ganguli, Runu, Chowdhury, Kanakendu, Chakbaborty, Bimal, Neogy, Rajat K.
Format: Artikel
Sprache:eng
Schlagworte:
Anthracycline
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Chromatin
Chromatin - metabolism
Chromosomal Proteins, Non-Histone - pharmacology
Daunorubicin - analogs & derivatives
Drug Interactions
Histones
Interaction
Medical sciences
Nogalamycin - metabolism
Pharmacology. Drug treatments
Protein Binding
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Zusammenfassung:Number of available nogalamycin binding sites in Sarcoma-180 chromatin is less than that present in Sarcoma-180 DNA. Gradual removal of proteins from chromatin by salt leads to increase in available drug binding sites, without appreciable alteration in binding affinity. Histones restrict the accessibility of nogalamycin to chromosomal DNA, whereas high mobility group (HMG) proteins have no effect. Association of histone H1 with chromosomal DNA has a more marked inhibitory effect on nogalamycin binding than other types of histones. Chromosomal protein induced conformational change in DNA appears to be the main factor in determining the availability of strong binding sites.
ISSN:0009-2797
1872-7786
DOI:10.1016/0009-2797(83)90018-2