Effects of intratracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lungs of hamsters
Intratracheal administration of one unit of bleomycin increased significantly the glucose-6-phosphate dehydrogenase activity to 147, 135, 163, 207, 278, and 148% of the control at 1, 2, 4, 7, 14, and 21 days post-treatment, respectively. The glutathione peroxidase activity was significantly increase...
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Veröffentlicht in: | Toxicology and applied pharmacology 1983-01, Vol.71 (1), p.132-141 |
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Sprache: | eng |
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Zusammenfassung: | Intratracheal administration of one unit of bleomycin increased significantly the glucose-6-phosphate dehydrogenase activity to 147, 135, 163, 207, 278, and 148% of the control at 1, 2, 4, 7, 14, and 21 days post-treatment, respectively. The glutathione peroxidase activity was significantly increased to 147 and 124% of the control at 7 and 14 days post-treatment, respectively. The glutathione reductase and catalase activities were significantly elevated to 132, 174, and 145% of the control in the former and 160, 213, and 160% of the control in the latter case at 7, 14, and 21 days post-treatment, respectively. The amount of thiobarbituric acid reacting products as an index of lipid peroxidation was found to be significantly increased to 251, 248, and 253% of the control at 4, 7, and 14 days after treatment, respectively. The amount of total lung collagen in treated hamsters was significantly increased to 140, 197, and 245% of the control at 7, 14, and 21 days post-treatment, respectively. These findings indicate that the increases in the activities of antioxidant enzymes in lungs of bleomycin-treated hamsters result from the multiple cytodynamic events such as infiltration of inflammatory cells, and reparative and proliferative processes which generally follow lung injury caused by any oxidant. |
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ISSN: | 0041-008X 1096-0333 |
DOI: | 10.1016/0041-008X(83)90052-2 |