NORTHIENAMYCIN AND 8-EPI-THIENAMYCIN, NEW CARBAPENEMS FROM STREPTOMYCES CATTLEYA
Two new carbapenem antibiotics, northienamycin and 8-epi-thienamycin have been isolated from culture broth of Streptomyces cattleya grown under conditions for thienamycin production. The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addit...
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| Veröffentlicht in: | Journal of antibiotics 1983, Vol.36(9), pp.1109-1117 |
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| container_end_page | 1117 |
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| container_issue | 9 |
| container_start_page | 1109 |
| container_title | Journal of antibiotics |
| container_volume | 36 |
| creator | WILSON, KENNETH E. KEMPF, AUGUST J. LIESCH, JERROLD M. ARISON, BYRON H. |
| description | Two new carbapenem antibiotics, northienamycin and 8-epi-thienamycin have been isolated from culture broth of Streptomyces cattleya grown under conditions for thienamycin production. The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addition, comparison of the in vitro potency of the correspond ing formamidine derivatives to that of MK787 is presented. |
| doi_str_mv | 10.7164/antibiotics.36.1109 |
| format | Article |
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The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addition, comparison of the in vitro potency of the correspond ing formamidine derivatives to that of MK787 is presented.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.36.1109</identifier><identifier>PMID: 6630073</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>8-epi-thienamycin ; Anti-Bacterial Agents - isolation & purification ; Antibiotics ; Antibiotics (antibacterial agents, antifungal agents) ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Applied microbiology ; Bacteria - drug effects ; Biological and medical sciences ; Biotechnology ; Chromatography, High Pressure Liquid ; Fundamental and applied biological sciences. Psychology ; Health. Pharmaceutical industry ; Industrial applications and implications. Economical aspects ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Microbiology ; northienamycin ; Production of active biomolecules ; Streptomyces - growth & development ; Streptomyces cattleya ; Structure-Activity Relationship ; Thienamycins - isolation & purification ; Thienamycins - toxicity</subject><ispartof>The Journal of Antibiotics, 1983, Vol.36(9), pp.1109-1117</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-7c5357c8b565ce82a9c0a33baabac51f9bc60bc92c25e3df796d4bd90a212ead3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9450025$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6630073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WILSON, KENNETH E.</creatorcontrib><creatorcontrib>KEMPF, AUGUST J.</creatorcontrib><creatorcontrib>LIESCH, JERROLD M.</creatorcontrib><creatorcontrib>ARISON, BYRON H.</creatorcontrib><title>NORTHIENAMYCIN AND 8-EPI-THIENAMYCIN, NEW CARBAPENEMS FROM STREPTOMYCES CATTLEYA</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Two new carbapenem antibiotics, northienamycin and 8-epi-thienamycin have been isolated from culture broth of Streptomyces cattleya grown under conditions for thienamycin production. The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addition, comparison of the in vitro potency of the correspond ing formamidine derivatives to that of MK787 is presented.</description><subject>8-epi-thienamycin</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Antibiotics</subject><subject>Antibiotics (antibacterial agents, antifungal agents)</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Applied microbiology</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health. Pharmaceutical industry</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>northienamycin</subject><subject>Production of active biomolecules</subject><subject>Streptomyces - growth & development</subject><subject>Streptomyces cattleya</subject><subject>Structure-Activity Relationship</subject><subject>Thienamycins - isolation & purification</subject><subject>Thienamycins - toxicity</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtP6zAQhS10EbcUfgG6UhZXrEjxI_FjGYqBSm1atUGIlTVxHAhKH8Tpgn9PqlZVN2NpzjdzxgehG4IHgvDoHlZtlVfrtrJ-wPiAEKzOUI9ISUIScfUH9TCmJJSS4r_o0vsvjJlgQl6gC84ZxoL10CydzrOXkU6TyftwlAZJ-hjIUM9G4Un3Lkj1WzBM5g_JTKd6sgie5tNJsMjmepZNO0QvOjXLxvo9uULnJdTeXR_ePnp90tnwJRxPn0fDZBxagWkbChuzWFiZxzy2TlJQFgNjOUAONialyi3HuVXU0tixohSKF1FeKAyUUAcF66Pb_d5Ns_7eOt-aZeWtq2tYufXWG8JERGX34z5ie9A2a-8bV5pNUy2h-TEEm12O5iRHw7jZ5dhN_Tus3-ZLVxxnDsF1-v-DDt5CXTawspU_YiqKu-zjDhvvsS_fwoc76tB0brU7tSaKy5292pfdFUfMfkJj3Ir9AmK7k1M</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>WILSON, KENNETH E.</creator><creator>KEMPF, AUGUST J.</creator><creator>LIESCH, JERROLD M.</creator><creator>ARISON, BYRON H.</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19830101</creationdate><title>NORTHIENAMYCIN AND 8-EPI-THIENAMYCIN, NEW CARBAPENEMS FROM STREPTOMYCES CATTLEYA</title><author>WILSON, KENNETH E. ; KEMPF, AUGUST J. ; LIESCH, JERROLD M. ; ARISON, BYRON H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-7c5357c8b565ce82a9c0a33baabac51f9bc60bc92c25e3df796d4bd90a212ead3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>8-epi-thienamycin</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Antibiotics</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Applied microbiology</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health. Pharmaceutical industry</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>northienamycin</topic><topic>Production of active biomolecules</topic><topic>Streptomyces - growth & development</topic><topic>Streptomyces cattleya</topic><topic>Structure-Activity Relationship</topic><topic>Thienamycins - isolation & purification</topic><topic>Thienamycins - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WILSON, KENNETH E.</creatorcontrib><creatorcontrib>KEMPF, AUGUST J.</creatorcontrib><creatorcontrib>LIESCH, JERROLD M.</creatorcontrib><creatorcontrib>ARISON, BYRON H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WILSON, KENNETH E.</au><au>KEMPF, AUGUST J.</au><au>LIESCH, JERROLD M.</au><au>ARISON, BYRON H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NORTHIENAMYCIN AND 8-EPI-THIENAMYCIN, NEW CARBAPENEMS FROM STREPTOMYCES CATTLEYA</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>36</volume><issue>9</issue><spage>1109</spage><epage>1117</epage><pages>1109-1117</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Two new carbapenem antibiotics, northienamycin and 8-epi-thienamycin have been isolated from culture broth of Streptomyces cattleya grown under conditions for thienamycin production. The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addition, comparison of the in vitro potency of the correspond ing formamidine derivatives to that of MK787 is presented.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>6630073</pmid><doi>10.7164/antibiotics.36.1109</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1983, Vol.36(9), pp.1109-1117 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13742800 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | 8-epi-thienamycin Anti-Bacterial Agents - isolation & purification Antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Bacteria - drug effects Biological and medical sciences Biotechnology Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microbiology northienamycin Production of active biomolecules Streptomyces - growth & development Streptomyces cattleya Structure-Activity Relationship Thienamycins - isolation & purification Thienamycins - toxicity |
| title | NORTHIENAMYCIN AND 8-EPI-THIENAMYCIN, NEW CARBAPENEMS FROM STREPTOMYCES CATTLEYA |
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