NORTHIENAMYCIN AND 8-EPI-THIENAMYCIN, NEW CARBAPENEMS FROM STREPTOMYCES CATTLEYA

Two new carbapenem antibiotics, northienamycin and 8-epi-thienamycin have been isolated from culture broth of Streptomyces cattleya grown under conditions for thienamycin production. The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addit...

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Veröffentlicht in:	Journal of antibiotics 1983, Vol.36(9), pp.1109-1117
Hauptverfasser:	WILSON, KENNETH E., KEMPF, AUGUST J., LIESCH, JERROLD M., ARISON, BYRON H.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-epi-thienamycin Anti-Bacterial Agents - isolation & purification Antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Bacteria - drug effects Biological and medical sciences Biotechnology Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microbiology northienamycin Production of active biomolecules Streptomyces - growth & development Streptomyces cattleya Structure-Activity Relationship Thienamycins - isolation & purification Thienamycins - toxicity
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Zusammenfassung:	Two new carbapenem antibiotics, northienamycin and 8-epi-thienamycin have been isolated from culture broth of Streptomyces cattleya grown under conditions for thienamycin production. The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addition, comparison of the in vitro potency of the correspond ing formamidine derivatives to that of MK787 is presented.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.36.1109