SAFRACINS, NEW ANTITUMOR ANTIBIOTICS: III. BIOLOGICAL ACTIVITY
Safracins A and B have antibacterial activity against Gram-positive and Gram-negative bacteria in vitro but no therapeutic activity in mice infected with Staphylococcus aureus. Safracins A and B induce abnormal morphological changes in Echerichia coli cells. Tests with transplantable mice tumors dem...
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| Veröffentlicht in: | Journal of antibiotics 1983, Vol.36(10), pp.1290-1294 |
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| container_end_page | 1294 |
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| container_issue | 10 |
| container_start_page | 1290 |
| container_title | Journal of antibiotics |
| container_volume | 36 |
| creator | IKEDA, YOSHIFUMI SHIMADA, YOSHIKO HONJO, KATSUHIKO OKUMOTO, TAKEKI MUNAKATA, TOMOHIKO |
| description | Safracins A and B have antibacterial activity against Gram-positive and Gram-negative bacteria in vitro but no therapeutic activity in mice infected with Staphylococcus aureus. Safracins A and B induce abnormal morphological changes in Echerichia coli cells. Tests with transplantable mice tumors demonstrate that safracins A and B inhibit the growth of P388 leukemia and IMC carcinoma. |
| doi_str_mv | 10.7164/antibiotics.36.1290 |
| format | Article |
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Tests with transplantable mice tumors demonstrate that safracins A and B inhibit the growth of P388 leukemia and IMC carcinoma.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.36.1290</identifier><identifier>PMID: 6358171</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Antibiotics, Antineoplastic - toxicity ; Biological and medical sciences ; Carcinoma - drug therapy ; Drug Evaluation, Preclinical ; Escherichia coli - drug effects ; Female ; General pharmacology ; Isoquinolines - therapeutic use ; Isoquinolines - toxicity ; Leukemia P388 - drug therapy ; Medical sciences ; Mice ; Mice, Inbred ICR ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Physicochemical properties. 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BIOLOGICAL ACTIVITY</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Safracins A and B have antibacterial activity against Gram-positive and Gram-negative bacteria in vitro but no therapeutic activity in mice infected with Staphylococcus aureus. Safracins A and B induce abnormal morphological changes in Echerichia coli cells. Tests with transplantable mice tumors demonstrate that safracins A and B inhibit the growth of P388 leukemia and IMC carcinoma.</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - toxicity</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - drug therapy</subject><subject>Drug Evaluation, Preclinical</subject><subject>Escherichia coli - drug effects</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Isoquinolines - therapeutic use</subject><subject>Isoquinolines - toxicity</subject><subject>Leukemia P388 - drug therapy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. 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Drug treatments</topic><topic>Physicochemical properties. Structure-activity relationships</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IKEDA, YOSHIFUMI</creatorcontrib><creatorcontrib>SHIMADA, YOSHIKO</creatorcontrib><creatorcontrib>HONJO, KATSUHIKO</creatorcontrib><creatorcontrib>OKUMOTO, TAKEKI</creatorcontrib><creatorcontrib>MUNAKATA, TOMOHIKO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IKEDA, YOSHIFUMI</au><au>SHIMADA, YOSHIKO</au><au>HONJO, KATSUHIKO</au><au>OKUMOTO, TAKEKI</au><au>MUNAKATA, TOMOHIKO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SAFRACINS, NEW ANTITUMOR ANTIBIOTICS: III. BIOLOGICAL ACTIVITY</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1983</date><risdate>1983</risdate><volume>36</volume><issue>10</issue><spage>1290</spage><epage>1294</epage><pages>1290-1294</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Safracins A and B have antibacterial activity against Gram-positive and Gram-negative bacteria in vitro but no therapeutic activity in mice infected with Staphylococcus aureus. Safracins A and B induce abnormal morphological changes in Echerichia coli cells. Tests with transplantable mice tumors demonstrate that safracins A and B inhibit the growth of P388 leukemia and IMC carcinoma.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>6358171</pmid><doi>10.7164/antibiotics.36.1290</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1983, Vol.36(10), pp.1290-1294 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13741331 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Antibiotics, Antineoplastic - toxicity Biological and medical sciences Carcinoma - drug therapy Drug Evaluation, Preclinical Escherichia coli - drug effects Female General pharmacology Isoquinolines - therapeutic use Isoquinolines - toxicity Leukemia P388 - drug therapy Medical sciences Mice Mice, Inbred ICR Microbial Sensitivity Tests Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Species Specificity |
| title | SAFRACINS, NEW ANTITUMOR ANTIBIOTICS: III. BIOLOGICAL ACTIVITY |
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