SAFRACINS, NEW ANTITUMOR ANTIBIOTICS: III. BIOLOGICAL ACTIVITY

Safracins A and B have antibacterial activity against Gram-positive and Gram-negative bacteria in vitro but no therapeutic activity in mice infected with Staphylococcus aureus. Safracins A and B induce abnormal morphological changes in Echerichia coli cells. Tests with transplantable mice tumors dem...

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Veröffentlicht in:	Journal of antibiotics 1983, Vol.36(10), pp.1290-1294
Hauptverfasser:	IKEDA, YOSHIFUMI, SHIMADA, YOSHIKO, HONJO, KATSUHIKO, OKUMOTO, TAKEKI, MUNAKATA, TOMOHIKO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - toxicity Biological and medical sciences Carcinoma - drug therapy Drug Evaluation, Preclinical Escherichia coli - drug effects Female General pharmacology Isoquinolines - therapeutic use Isoquinolines - toxicity Leukemia P388 - drug therapy Medical sciences Mice Mice, Inbred ICR Microbial Sensitivity Tests Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Species Specificity
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Zusammenfassung:	Safracins A and B have antibacterial activity against Gram-positive and Gram-negative bacteria in vitro but no therapeutic activity in mice infected with Staphylococcus aureus. Safracins A and B induce abnormal morphological changes in Echerichia coli cells. Tests with transplantable mice tumors demonstrate that safracins A and B inhibit the growth of P388 leukemia and IMC carcinoma.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.36.1290