Effects of 6 months glucagon-like peptide-1 receptor agonist treatment on endothelial function in type 2 diabetes mellitus patients

Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) are used for treatment in type 2 diabetes mellitus (T2DM). Little is known about their cardiovascular (CV) impact. We sought to determine the effects of chronic treatment on vascular function in T2DM. Brachial artery endothelial‐dependent flow‐med...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2013-08, Vol.15 (8), p.770-773
Hauptverfasser:	Hopkins, N. D., Cuthbertson, D. J., Kemp, G. J., Pugh, C., Green, D. J., Cable, N. T., Jones, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue Blood Glucose Body Mass Index Brachial Artery - physiopathology Carotid Arteries - physiopathology carotid intima-medial thickness Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diabetic Angiopathies - drug therapy Diabetic Angiopathies - physiopathology Diabetic Angiopathies - prevention & control endothelial function Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Female GLP-1 receptor agonists Glucagon-Like Peptide-1 Receptor Glycated Hemoglobin A Humans Hypoglycemic Agents - therapeutic use Magnetic Resonance Imaging Male Metformin - therapeutic use Middle Aged obesity Obesity - blood Obesity - complications Obesity - physiopathology Oxidative Stress Receptors, Glucagon - agonists type 2 diabetes mellitus
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Zusammenfassung:	Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) are used for treatment in type 2 diabetes mellitus (T2DM). Little is known about their cardiovascular (CV) impact. We sought to determine the effects of chronic treatment on vascular function in T2DM. Brachial artery endothelial‐dependent flow‐mediated dilation (FMD) and endothelial‐independent glyceryl trinitrate (GTN) function and carotid intima‐medial thickness (cIMT) were assessed in 11 severely obese T2DMs (4 females, 7 males: 55 ± 8 years, diabetes duration 8.3 ± 4.7 years mean ± s.d.) before and after 6 months GLP‐1 RA. Body weight (5.3 ± 1.2 kg; p
ISSN:	1462-8902 1463-1326
DOI:	10.1111/dom.12089