Effects of inhaled TiO(2) nanotubes on lung tissue and serum biochemical indexes of mice

To evaluate the acute lung toxicity and the effect on serum biochemical indexes of inhaled TiO(2) nanotubes, healthy and adult Kunming mice are exposed to aerosols of TiO(2) nanotubes in a sealed chamber, the concentration of which is 250 mg/m(3) while another group of mice are exposed to room air o...

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Veröffentlicht in:Transactions of Nanjing University of Aeronautics & Astronautics 2013-03, Vol.30 (1), p.96-103
Hauptverfasser: Tao, Jie, He, Pinting, Zhang, Yanyan, Tang, Yuxin, Wang, Yueqin
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Sprache:eng
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Zusammenfassung:To evaluate the acute lung toxicity and the effect on serum biochemical indexes of inhaled TiO(2) nanotubes, healthy and adult Kunming mice are exposed to aerosols of TiO(2) nanotubes in a sealed chamber, the concentration of which is 250 mg/m(3) while another group of mice are exposed to room air only served as control. The blood, alveolar lavaged fluid and lungs of the mice are collected and examined after exposed for 7, 14 and 28 d, respectively. The serum analysis shows that glucose(Glu) values with 7 d exposure, alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activities with 28 d inhalation, and total bile acid(TBA) values with 7, 28 d as well as the creatine kinase(CK) levels with 28 d exposure are significantly different from those of controls (P
ISSN:1005-1120